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splenic marginal zone B-cell lymphoma
B cell neoplasm of small lymphocytes which surround and replace splenic white pulp germinal centers, efface follicle mantle and merge with marginal zone of larger cells.
Classification: working formulation category/Lukes-Collins: small lymphocytic lymphoma Rappaport: well differentiated lymphocytic lymphoma
Microscopic pathology:
Immunophenotype:
- surface IgM and IgD +
- CD5 -
- CD10 -
- CD20 +
- CD23 -
- CD43 -
- CD79a +
- CD103 -
- cyclin D1 -
Interactions
disease interactions
General
marginal zone B-cell lymphoma
small lymphocytic lymphoma
References
- Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML,
Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al.
A revised European-American classification of lymphoid
neoplasms: a proposal from the International Lymphoma Study
Group.
Blood. 1994 Sep 1;84(5):1361-92. Review.
PMID: 8068936
- Chan JK, Banks PM, Cleary ML, Delsol G, De Wolf-Peeters C,
Falini B, Gatter KC, Grogan TM, Harris NL, Isaacson PG, et al.
A revised European-American classification of lymphoid
neoplasms proposed by the International Lymphoma Study Group.
A summary version.
Am J Clin Pathol. 1995 May;103(5):543-60.
PMID: 7741099
- WHO Classification Tumours of Haematopoietic and Lymphoid
Tissues. IARC Press 2001.