group 2D secretory phospholipase A2; GIID sPLA2; sPLA2-IID; PLA2IID; phosphatidylcholine 2-acylhydrolase 2D; secretory-type PLA, stroma-associated homolog (PLA2G2D, SPLASH)

Function: - PA2 catalyzes the Ca⁺²-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides - L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than other phospholipids examined phosphatidylcholine + H₂O = 1-acylglycerophosphocholine + a carboxylate Cofactor: binds 1 Ca⁺² per subunit Kinetic parameters: - pH dependence: optimally active at neutral to alkaline pHs with 2 mM Ca⁺² Structure: belongs to the phospholipase A2 family Compartment: secreted (putative) Expression: broadly expressed

General

Ca+2 binding protein glycoprotein phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2) secreted protein

Properties

SIZE: entity length = 145 aa MW = 17 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-20} cysteine residue {C46} MODIFICATION: cysteine residue {C138} Ca+2-binding site SITE: 47-47 cysteine residue {C48} MODIFICATION: cysteine residue {C64} Ca+2-binding site SITE: 49-49 Ca+2-binding site SITE: 51-51 cysteine residue {C63} MODIFICATION: cysteine residue {C118} cysteine residue {C64} MODIFICATION: cysteine residue {C48} histidine residue {H67} Ca+2-binding site SITE: 68-68 cysteine residue {C69} MODIFICATION: cysteine residue {C145} cysteine residue {C70} MODIFICATION: cysteine residue {C111} cysteine residue {C79} MODIFICATION: cysteine residue {C104} N-glycosylation site {N89} cysteine residue {C97} MODIFICATION: cysteine residue {C109} cysteine residue {C104} MODIFICATION: cysteine residue {C79} cysteine residue {C109} MODIFICATION: cysteine residue {C97} cysteine residue {C111} MODIFICATION: cysteine residue {C70} aspartate residue {D112} cysteine residue {C118} MODIFICATION: cysteine residue {C63} cysteine residue {C138} MODIFICATION: cysteine residue {C46} cysteine residue {C145} MODIFICATION: cysteine residue {C69}

Database Correlations

OMIM 605630 UniProt Q9UNK4 Pfam PF00068 Entrez Gene 26279 Kegg hsa:26279 ENZYME 3.1.1.4