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serine protease inhibitor Kazal-type 1; pancreatic secretory trypsin inhibitor; tumor-associated trypsin inhibitor; TATI (SPINK1, PSTI)
Function:
- prevents trypsin-catalyzed premature activation of zymogens within the pancreas
Structure: contains 1 Kazal-like domain
Compartment: secreted
Pathology:
- defects in SPINK1 are a cause of chronic pancreatitis
- defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis
General
Kazal type serine protease inhibitor
trypsin inhibitor
Properties
INHIBITS: trypsin
SIZE: entity length = 79 aa
MW = 9 kD
MOTIF: signal sequence {1-23}
Kazal-type serine protease inhibitor domain {26-79}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
cysteine residue {C32}
MODIFICATION: cysteine residue {C61}
cysteine residue {C39}
MODIFICATION: cysteine residue {C58}
peptide motif {41-42}
cysteine residue {C47}
MODIFICATION: cysteine residue {C79}
cysteine residue {C58}
MODIFICATION: cysteine residue {C39}
cysteine residue {C61}
MODIFICATION: cysteine residue {C32}
cysteine residue {C79}
MODIFICATION: cysteine residue {C47}
FOR-BINDING-OF: serine protease
Database Correlations
OMIM correlations
MORBIDMAP 167790
UniProt P00995
Pfam PF00050
Entrez Gene 6690
Kegg hsa:6690
References
- UniProt :accession P00995
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/SPINK1