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transcription factor spi-B (SPIB)
Function:
- sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer
- promotes development of plasmacytoid dendritic cells
- may be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development & antigenic stimulation
- can form homotypic interactions
- interacts with IRF4
- may also interact with CREBBP, EP300, SPI1/PU.1 related, JUN & TBP
Structure:
- the protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich in Pro, Ser & Thr
- each of these domains may be required for transcriptional activation of a subset of target genes
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
Compartment:
- isoform 1: nucleus
- isoform 2: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- expressed in plasmacytoid dendritic cells & B-cells
- not expressed in T-cells or granulocytes
- may also be enriched in stem cell populations of the liver
General
Ets family protein
Properties
SIZE: entity length = 262 aa
MW = 29 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: TAD1 (Acidic) {1-31}
TAD2 {41-61}
ETS domain
NAME: ETS domain
SITE: 169-252
Database Correlations
OMIM 606802
UniProt Q01892
Pfam PF00178
Kegg hsa:6689
References
UniProt :accession Q01892