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Sphingosine kinase 1
Function:
1) catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate
2) binds to calmodulin
sphingosine + ATP sphingosine 1-phosphate + ADP
Cofactor: Mg+2
Kinetic parameters:
- KM=14 uM for sphingosine
- KM=20 uM for dihydrosphingosine
- KM=77 uM for ATP
- Optimum pH is 7.4
Structure: contains 1 DAGKc domain
Expression:
- widely expressed
- highest levels in adult liver, kidney, heart, skeletal muscle
Related
ceramide kinase; hCERK; acylsphingosine kinase; lipid kinase 4; LK4 (CERK, KIAA1646)
sphingosine
General
kinase or ATP-phosphotransferase
Properties
SIZE: entity length = 384 aa
MW = 43 kD
MOTIF: DAGKc {16-153}
Database Correlations
OMIM 603730
UniProt Q9NYA1
Entrez Gene 8877
ENZYME 2.7.1.91
References
UniProt :accession Q9NYA1