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sphingosine-1-phosphate (S1P)
CH3(CH2)12-CH=CHCHCHCH2-OH
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-O3PO NH2
Extremely insoluble.
Function:
- bioactive lysophospholipid that elicits diverse physiological effect on most types of cells & tissues
- lipid mediator with both intra- & extracellular functions
- mitogen & tumor promoter
- effects of S1P are mediated by a specific family of G protein-coupled sphingosine 1-phosphate receptors
- chemotractic factor for hematopoietic progenitor cells
- attracts peripheral blood CD34(+) cells in vitro
- activates p38 MAP kinase (stress-induced kinase)
Compartment:
- ubiquitously present extracellular lipid mediator released by several cell types, especially by activated platelets
Related
sphingosine
sphingosine 1-phosphate receptor; S1P receptor (S1PR)
sphingosine-1-phosphate lyase 1 (SP-lyase, hSPL, sphingosine-1-phosphate aldolase, SGPL1, KIAA1252)
sphingosine-1-phosphate phosphatase 1; SPPase1; Spp1; hSPP1; hSPPase1; sphingosine-1-phosphatase 1 (SGPP1)
General
amino alcohol
phosphomonoester
Database Correlations
PUBCHEM correlations