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speech-language disorder 1; specific language impairment; developmental verbal dyspraxia (SPCH1)
Genetics:
- autosomal dominant
-> associated with mutation in gene for forkhead box protein P2
Clinical manifestations:
1) failure to develop language normally in the absence of hearing impairment of neurological disorder
2) severe speech disorder & language disorder
3) severe impairment in the selection & sequencing of fine orofacial movements necessary for articulation
4) deficits in several facets of language processing, including ability to break up words into their constituent phonemes
5) selective impairment in grammar
Related
forkhead box protein P2; CAG repeat protein 44; trinucleotide repeat-containing gene 10 protein (FOXP2)
General
speech-language disorder; specific language impairment; developmental verbal dyspraxia
Database Correlations
OMIM 602081
References
OMIM :accession 602081