Search
sparfloxacin (Zagam)
Tradename: Zagam.
Indications:
- bacterial infections due to susceptible organisms
- pneumonia [3]
Dosage: 400 mg PO loading dose, then 200 mg PO QD.
Tabs: 200 mg.
Dosage adjustment in renal failure:
creatinine clearance dosage
> 50-90 mL/min 200 mg PO QD
10-50 mL/min 100-150 mg PO QD
< 10 mL/min* 100 mg PO every 48 hours
* same dosing for hemodialysis
Pharmacokinetics:
-> elimination 1/2life 15-20 hours (38 hours ESRD)
Antimicrobial activity:
Gram positive
- Streptococcus
- Streptococcus group A
- Streptococcus group B
- Streptococcus group C
- Streptococcus group G
- Streptococcus pneumonia
- Streptococcus viridans, milleri
- Enterococcus faecalis
- Enterococcus faecium
- Staphylococcus aureus (MSSA)
- Staphylococcus aureus (MRSA)
- Staphylococcus epidermidis
Gram negative
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Moraxella catarrhalis
- Haemophilus influenzae
- Haemophilus parainfluenzae [3]
- Escherichia coli
- Klebsiella species
- Enterobacter species
- Serratia species
- Salmonella species
- Shigella species
- Proteus mirabilis
- Proteus vulgaris
- Providencia species
- Morganella species
- Chlamydophila pneumoniae [3]
- Citrobacter species
- Aeromonas species
- Acinetobacter species
- Xanthomonas maltophilia (+/-)
- Yersinia enterocolitica
- Legionella species
- Pasteurella multocida
Atypical bacteria
- Chlamydia species
- Mycoplasma pneumonia
Anaerobes
- Peptostreptococcus species
Interactions
drug interactions
drug adverse effects of fluoroquinolones
General
fluoroquinolone
Properties
INHIBITS: DNA gyrase
MISC-INFO: elimination route KIDNEY
LIVER
1/2life <20 HOURS
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Sanford Guide to antimicrobial therapy 1997.
- Deprecated Reference