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transcription factor Sp3; stimulatory protein 3 (Sp3, SPR-2)
Function:
- transcriptional factor that can act as an activator or repressor, probably in a isoform-specific manner
- binds to GT & GC boxes promoters elements
Structure:
- belongs to the Sp1 C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing:
- named isoforms=6
- alternative initiation
- AUA codon is translated into Met & used as a translation initiation site (in vitro)
Expression:
- ubiquitously expressed
General
C2H2 type zinc finger protein
phosphoprotein
Sp1 transcription factor family
Properties
SIZE: entity length = 781 aa
MW = 82 kD
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {21-31}
glutamine-rich region {35-39}
MOTIF: glutamine residue (SEVERAL)
alanine-rich region {44-100}
MOTIF: alanine residue (SEVERAL)
Ser phosphorylation site {S73}
transcriptional activation domain
SITE: 138-237
transcriptional activation domain
SITE: 350-499
Repressor {534-620}
MOTIF: Ser phosphorylation site {S563}
Ser phosphorylation site {S566}
Zn finger C2H2-type
SITE: 621-645
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S646}
Zn finger C2H2-type
SITE: 651-675
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 681-703
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 601804
UniProt Q02447
Pfam PF00096
Entrez Gene 6670
Kegg hsa:6670
References
UniProt :accession Q02447