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sry-box-6 protein; transcription factor SOX-6 (sox6)
Function:
- transcriptional activator
- binds specifically to the DNA sequence 5'-AACAAT-3'
- plays a key role in several developmental processes, including neurogenesis & skeleton formation
- interacts with DAZAP2 (putative)
- sumoylation inhibits the transcriptional activity
Structure: contains 1 HMG box DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- expressed in a wide variety of tissues
- highest expression in skeletal muscle
General
sex-determining region Y box protein; sry-box protein; sox protein (SOX)
Properties
SIZE: MW = 92 kD
entity length = 828 aa
COMPARTMENT: cell nucleus
MOTIF: coiled coil {184-262}
MOTIF: glutamine-rich region {219-261}
MOTIF: glutamine residue (SEVERAL)
alanine-rich region {280-285}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {313-317}
MOTIF: alanine residue (SEVERAL)
HMG box
SITE: 621-689
Database Correlations
UniProt P35712
Pfam PF00505
Entrez Gene 55553
Kegg hsa:5555
References
UniProt :accession P35712