Search
son of sevenless homolog protein 2 (Sos2)
Function:
- promotes the exchange of Ras-bound GDP by GTP
Structure:
- contains 1 DH (DBL-homology) domain contains 1 N-terminal Ras-GEF domain contains 1 PH domain contains 1 Ras-GEF domain
General
son of sevenless homolog protein (SOS)
Properties
SIZE: entity length = 1332 aa
MW = 153 kD
MOTIF: Dbl homology domain {198-388}
PH domain {442-546}
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 595-739
proline-rich region
SITE: 755-758
MOTIF: proline residue (SEVERAL)
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 778-1017
proline-rich region
SITE: 1180-1183
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 1203-1208
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 601247
UniProt Q07890
PFAM correlations
References
- UniProt :accession Q07890
- Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA.
Association of Sos Ras exchange protein with Grb2 is
implicated in tyrosine kinase signal transduction and
transformation.
Nature. 1993 May 6;363(6424):45-51.
PMID: 8479536
- Wikipedia; Son of sevenless entry
http://en.wikipedia.org/wiki/Son_of_Sevenless