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son of sevenless homolog protein 1 (Sos1)

Function: - promotes the exchange of Ras-bound GDP by GTP - interacts with GRB2 - interacts with phosphorylated LAT2 Structure: - contains 1 DH (DBL-homology) domain contains 1 N-terminal Ras-GEF domain contains 1 PH domain contains 1 Ras-GEF domain Expression: expressed in gingival tissues Pathology: - defects in SOS1 are the cause of gingival fibromatosis 1 - defects in SOS1 are the cause of Noonan syndrome type 4

Interactions

molecular events

Related

ras signal transduction SOS1 gene mutation

General

son of sevenless homolog protein (SOS)

Properties

SIZE: entity length = 1333 aa MW = 152 kD MOTIF: Dbl homology domain {200-390} PH domain {444-548} guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 597-741 guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 780-1019 Ser phosphorylation site {S1043} Ser phosphorylation site {S1078} Ser phosphorylation site {S1082} Ser phosphorylation site {S1210} proline-rich region SITE: 1258-1261 FOR-BINDING-OF: growth factor receptor-bound protein-2 (grb2) RAS-GNRP-C3G MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM correlations UniProt Q07889 PFAM correlations

References

  1. Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature. 1993 May 6;363(6424):45-51. PMID: 8479536
  2. Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science. 1993 May 28;260(5112):1338-43. PMID: 8493579
  3. Boguski MS, McCormick F. Proteins regulating Ras and its relatives. Nature. 1993 Dec 16;366(6456):643-54. Review. PMID: 8259209
  4. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=SOS1
  5. Wikipedia; Note=Son of sevenless entry http://en.wikipedia.org/wiki/Son_of_Sevenless
  6. UniProt :accession Q07889

Component-of

molecular complex