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son of sevenless homolog protein (SOS)

A ras guanine nucleotide exchange factor.

Interactions

molecular events

Specific

son of sevenless homolog protein 1 (Sos1) son of sevenless homolog protein 2 (Sos2)

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)

Properties

MOTIF: binding site FOR-BINDING-OF: ras proto-oncogene protein (p21ras) MOTIF: active site domain (3) HOMOLOGY: ras guanine nucleotide releasing factor 1 son of sevenless homolog protein (SOS) cdc25 protein Sdc25 protein proline-rich region SITE: C-TERMINAL FOR-BINDING-OF: growth factor receptor-bound protein-2 (grb2) MOTIF: proline residue (SEVERAL)

References

  1. Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature. 1993 May 6;363(6424):45-51. PMID: 8479536
  2. McCormick F. Signal transduction. How receptors turn Ras on. Nature. 1993 May 6;363(6424):15-6. No abstract available. PMID: 8479530
  3. Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science. 1993 May 28;260(5112):1338-43. PMID: 8493579

Component-of

molecular complex