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somatotropin; growth hormone; somatropin (GH)
Function:
- stimulates growth & cell reproduction
- stimulates IGF-1 secretion
Compartment: secreted
Expression:
- secreted by somatotrophs in the lateral anterior pituitary
- secretion inhibited by somatostatin, dietary carbohydrate, glucocorticoids
- feedback inhibition by IGF1 & somatotropin
- secretion stimulated by GHRH, ghrelin, arginine, sleep, exercise, hypoglycemia, estradiol
- secretion is pulsatile, 10-30 minute pulses (5-35 ng/mL)
- amplitude & frequency of peaks greatest during prepubertal growth spurt
- healthy adolescent & children average 8 peaks/day; health adults average 5 peaks/day
- largest & most predictable peak occurs 1 hour after onset of sleep
- basal levels (< 3 ng/mL) & frequency & amplitude of pulses declines throughout adult life
Pathology:
- may promote growth of cancers: colon cancer, lung cancer, breast cancer [1]
Pharmacology: see Humatrope
Related
acromegaly
growth hormone (GH) stimulation test
growth hormone (GH) suppression test; glucose challenge test for acromegaly
growth hormone (somatotropin) in serum
growth hormone receptor; GH receptor; somatotropin receptor; contains: growth hormone-binding protein; GH-binding protein; GHBP; serum-binding protein (GHR)
growth hormone-releasing hormone; somatotropin-releasing hormone,; somatocrinin; somatoliberin (GHRH)
pituitary adenoma/GH secreting (somatotrophinoma)
somatotropin; growth hormone; somatropin (GH)
Specific
lanreotide (somatotropin, growth hormone, GH, hGH, rhGH, Humatrope, Protropin, Serostim, Somatrem, Somatuline)
somatotropin 2; growth hormone 2; growth hormone variant; placenta-specific growth hormone; placental somatotropin (GH2)
somatotropin-1; growth hormone; GH; GH-N; growth hormone 1; pituitary growth hormone (GH1)
somatrogon-ghla (Ngenla)
General
anterior pituitary hormone
Properties
COMPARTMENT: plasma
References
- Wikipedia, Growth hormone
http://en.wikipedia.org/wiki/somatotropin