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somatostatinoma

Pathology: 1) tumor of pancreatic islet D cells 2) 70% malignant Clinical manifestations: 1) diarrhea 2) steatorrhea 3) diabetes mellitus 4) gallstones Laboratory: - serum somatostatin is elevated [3] - see ARUP consult [2]

Related

somatostatin; growth hormone release-inhibiting factor; contains: somatostatin-28, somatostatin-14 (SST)

General

amine precursor uptake & decarboxylation tumor (APUDoma) islet cell tumor; pancreatic neuroendocrine neoplasm; nesidioblastoma

References

  1. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 585
  2. ARUP Consult: Somatostatinoma The Physician's Guide to Laboratory Test Selection & Interpretation https://arupconsult.com/content/somatostatinoma
  3. Medical Knowledge Self Assessment Program (MKSAP) 17, 18, American College of Physicians, Philadelphia 2015, 2018