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somatostatin receptor 2; SS2R; SRIF-1 (SSTR2)
Function:
- receptor for somatostatin-14 & somatostatin-28.
- coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase
- additionally, stimulates phosphotyrosine phosphatase & PLC via G proteins (both pertussis toxin sensitive & insensitive)
- in RIN-5F cells, inhibits Ca+2 entry by suppressing voltage-dependent Ca+2-channels
- C-terminus interacts with SHANK1 PDZ domain
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=2 (SSTR2A, SSTR2B)
Expression:
- cerebrum & kidney
- lesser expression in jejunum, colon & liver
General
somatostatin receptor
Properties
SIZE: entity length = 369 aa
MW = 41 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-43}
MOTIF: N-glycosylation site {N9}
N-glycosylation site {N22}
N-glycosylation site {N29}
N-glycosylation site {N32}
transmembrane domain {44-67}
cytoplasmic loop {68-78}
transmembrane domain {79-103}
exoplasmic loop {104-118}
MOTIF: cysteine residue {C115}
MODIFICATION: cysteine residue {C193}
transmembrane domain {119-138}
cytoplasmic loop {139-161}
transmembrane domain {162-181}
exoplasmic loop {182-207}
MOTIF: cysteine residue {C193}
MODIFICATION: cysteine residue {C115}
transmembrane domain {208-229}
cytoplasmic loop {230-253}
transmembrane domain {254-278}
exoplasmic loop {279-288}
transmembrane domain {289-303}
cytoplasmic domain {304-369}
MOTIF: cysteine residue {C328}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 182452
UniProt P30874
Pfam PF00001
Entrez Gene 6752
Kegg hsa:6752
References
UniProt :accession P30874