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insulin-like growth factor-1; mechano growth factor; MGF; somatomedin-C (IGF1, IBP1)

Function: - structurally & functionally related to insulin but with a much higher growth-promoting activity - 85% bound in molecular complex with IGF-binding protein 3 & acid labile subunit glycoprotein. - may enhance growth of tumors. [3] - may be a physiological regulator of glucose transport & glycogen synthesis in osteoblasts Structure: belongs to the insulin family Compartment: - plasma - secreted by liver in response to growth hormone Alternate splicing: - forms IGF-1A & IGF-1B - named isoforms=4 Expression: - secreted by liver in response to growth hormone Pathology: - IGF1 deficiency is an autosomal recessive disorder - low plasma IGF-1 levels predicts life expectancy in exceptionally long-lived women & persons of either gender with history of cancer [8] Pharmacology: -> NOT effective as a pharmaceutical agent [2]

Related

IGF-1 gene insulin-like growth factor (IGF)-1 or somatomedin C in serum insulin-like growth factor [IGF]-1 receptor (somatomedin-C receptor, CD221, IGF1R) somatotropin; growth hormone; somatropin (GH)

Specific

mecasermin (Increlex, Insmed, recombinant IGF1)

General

multisubunit protein peptide precursor somatomedin

Properties

SIZE: entity length = 195 aa MW = 22 kD MW = 7 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-21} B {49-77} MOTIF: cysteine residue {C54} MODIFICATION: cysteine residue {C96} cysteine residue {C66} MODIFICATION: cysteine residue {C109} C {78-89} A {90-110} MOTIF: cysteine residue {C95} MODIFICATION: cysteine residue {C100} cysteine residue {C96} MODIFICATION: cysteine residue {C54} cysteine residue {C100} MODIFICATION: cysteine residue {C95} cysteine residue {C109} MODIFICATION: cysteine residue {C66} D {111-118} SECRETED-BY: macrophage GENE: IGF-1 gene

Database Correlations

OMIM correlations UniProt P05019 Pfam PF00049 Entrez Gene 3479 Kegg hsa:3479

References

  1. Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908
  2. Solomon DH, in: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  3. LeRoith D IGF-1, Cancer and Aging Aging: Mechanisms and Prevention 34th Annual Meeting of the American Aging Association June 3-6, 2005, Oakland CA
  4. UniProt :accession P05019
  5. SHMPD; Note: Singapore human mutation andpolymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HLA-DQB1
  6. NIEHS-SNPs http://egp.gs.washington.edu/data/igf1/
  7. Wikipedia; Note: insulin-like growth factor 1 entry http://en.wikipedia.org/wiki/insulin-like_growth_factor_1
  8. Milman S, Atzmon G, Huffman DM et al Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell. 2014 Aug;13(4):769-71. PMID: 24618355 Free PMC Article

Component-of

IGF-1/IGF binding protein 3/acid-labile subunit glycoprotein