Na+/glucose cotransporter 2; Na+/glucose cotransporter like; low affinity Na+ glucose cotransporter; solute carrier family 5 member 2 (SLC5A2, SGLT2)

Function: - Na⁺ dependent glucose transporter - has a Na⁺ to glucose coupling ratio of 1:1 - efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity & a high affinity low capacity Na⁺/glucose cotransporter arranged in series along kidney proximal tubules Structure: - belongs to the Na⁺:solute symporter (SSF) (TC 2.A.21) family Compartment: membrane Pathology: - defects in SLC5A2 are the cause of renal glucosuria Pharmacology: - SGLT2 inhibitors for treatment of diabetes mellitus type-2

General

glucose transporter transmembrane 11 protein

Properties

SIZE: entity length = 672 aa MW = 73 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-25} transmembrane domain {26-44} MOTIF: glycine residue {40} exoplasmic loop {45-61} transmembrane domain {62-82} cytoplasmic loop {83-102} transmembrane domain {103-123} exoplasmic loop {124-168} transmembrane domain {169-188} cytoplasmic loop {189-205} transmembrane domain {206-226} exoplasmic loop {227-270} MOTIF: N-glycosylation site {N250} transmembrane domain {271-291} cytoplasmic loop {292-314} MOTIF: arginine residue {300} transmembrane domain {315-334} exoplasmic loop {335-423} MOTIF: N-glycosylation site {N399} transmembrane domain {424-443} cytoplasmic loop {444-455} transmembrane domain {456-476} exoplasmic loop {477-526} transmembrane domain {527-547} cytoplasmic loop {548-650} transmembrane domain {651-671} exoplasmic domain {672-672}

Database Correlations

OMIM correlations UniProt P31639 Pfam PF00474 Kegg hsa:6524