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Mn+2 superoxide dismutase (SOD-2, Mn-SOD, SOD2)
Function:
- destroys O2- radicals which are normally produced within cells & which are toxic to biological systems
- acetylation at Lys-122 decreases enzymatic activity
- deacetylated by SIRT3 upon exposure to ionizing radiation or after long fasting (putative)
- nitrated under oxidative stress
- nitration coupled with oxidation inhibits the catalytic activity
2 O2- + 2 H+ = O2 + H2O2
Cofactor: binds 1 Mn+2 per subunit
Structure:
- homotetramer
- belongs to the iron/Mn+2 superoxide dismutase family
Compartment: mitochondria matrix
Alternative splicing: named isoforms=4
Expression:
- expression is regulated by KRIT1
Pathology:
- genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes mellitus [6]
General
human longevity protein
mitochondrial protein
oligomerizing protein
superoxide dismutase
Properties
SIZE: entity length = 222 aa
MW = 25 kD
COMPARTMENT: mitochondrial matrix
MOTIF: manganese [Mn]-binding site
SITE: 50-50
manganese [Mn]-binding site
SITE: 98-98
manganese [Mn]-binding site
SITE: 183-183
manganese [Mn]-binding site
SITE: 187-187
Database Correlations
OMIM correlations
UniProt P04179
PFAM correlations
Entrez Gene 6648
Kegg hsa:6648
ENZYME 1.15.1.1
References
- Harris ED
Regulation of antioxidant enzymes.
FASEB J 6:2675 1992
PMID: 1612291
- UniProt :accession P04179
- SHMPD; The Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=SOD2
- Wikipedia; superoxide dismutase entry
http://en.wikipedia.org/wiki/superoxide_dismutase
- NIEHS-SNPs
http://egp.gs.washington.edu/data/sod2/
- OMIM :accession 612634