sorting nexin-2; transformation-related gene 9 protein; TRG-9 (SNX2)

Function: - may be involved in several stages of intracellular trafficking - component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R & M6PR) from endosomes to the trans-Golgi network - interacts with FNBP1 Structure: - belongs to the sorting nexin family - contains 1 PX (phox homology) domain

General

phosphoprotein sorting nexin

Properties

SIZE: entity length = 519 aa MW = 58 kD MOTIF: Ser phosphorylation site {S119} PX domain {140-269} MOTIF: SH3-binding site NAME: SH3-binding site Ser phosphorylation site {S185} Ser phosphorylation site {S277}

Database Correlations

OMIM 605929 UniProt O60749 PFAM correlations Entrez Gene 6643 Kegg hsa:6643

References

UniProt :accession O60749