snurportin-1 (RNA U transporter 1, SNUPN, RNUT1, SPN1)

Function: 1) U snRNP-specific nuclear import adapter 2) trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs 3) binds specifically to the terminal m3G-cap U snRNAs 4) component of an import snRNP complex 5) component of a nuclear export receptor complex 6) interacts with DDX20, IPO7, KPNB1, SMN1, SNRPB & XPO1 7) interacts directly with XPO1 - interaction with XPO1 & binding to m3G-cap U snRNPs are mutually exclusive (putative) 8) nucleoplasmic shuttling protein - nuclear import involves the nucleocytoplasmic transport receptor importin beta - reexported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway Compartment: nucleus, cytoplasm

Properties

SIZE: MW = 41 kD entity length = 360 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: binding site SITE: 1-159 FOR-BINDING-OF: exportin 1 MOTIF: KPNB1... interaction {1-65} IBB {11-73} binding site SITE: 208-328 FOR-BINDING-OF: 2,2,7 trimethylated inverted GTP 5' cap structure

Database Correlations

OMIM 607902 UniProt O95149

References

UniProt :accession O95149