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gamma-2-syntrophin; G2SYN; syntrophin-5; SYN5 (SNTG2)
Function:
- adapter protein
- binds to & probably organizes the subcellular localization of a variety of proteins
- may link various receptors to the actin cytoskeleton & the dystrophin glycoprotein complex (putative)
- interacts with the dystrophin protein DMD & related proteins DTNA & DTNB
Structure:
- association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (putative)
- belongs to the syntrophin family
- contains 1 PDZ domain (DHR domain)
- contains 1 PH domain
Compartment:
- cell membrane, sarcolemma
- peripheral membrane protein; cytoplasmic side
- cytoplasm, cytoskeleton
- in skeletal muscle, localizes at the cytoplasmic side of the sarcolemmal membrane
- in CNS, expressed in the perikaryon & proximal portion of neuronal processes
Expression:
- widely expressed
- strong expression in brain & testis
- strong expression in the hippocampus, neuron-rich dendate granule cells, & pyramidal cell layers
- highly expressed in neurons of the cerebral cortex
- also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, & basal ganglia
General
syntrophin (dystrophin-associated protein)
Properties
SIZE: entity length = 539 aa
MW = 60 kD
COMPARTMENT: cytoplasm
MOTIF: proline-rich region
SITE: 6-9
MOTIF: proline residue (SEVERAL)
PDZ domain
NAME: PDZ domain
SITE: 73-156
DHR domain
PH domain {296-421}
Database Correlations
OMIM 608715
UniProt Q9NY99
Pfam PF00595
Entrez Gene 54221
Kegg hsa:54221
References
- UniProt :accession Q9NY99
- Entrez Gene :accession 54221