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gamma-1-syntrophin; G1SYN; syntrophin-4; SYN4 (SNTG1)
Function:
- adapter protein
- binds to & probably organizes subcellular localization of a variety of proteins
- may link various receptors to the actin cytoskeleton & the dystrophin glycoprotein complex (putative)
- may participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation
- isoform 1, but not isoform 2, interacts with the dystrophin protein DMD & related proteins DTNA & DTNB
- interacts with DGKZ
Structure:
- the PDZ domain binds to the last 3 or fo4 amino acids of DGKZ
- association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane
- belongs to the syntrophin family
- contains 1 PDZ domain (DHR domain)
- contains 1 PH domain
Compartment:
- cytoplasm, cytoskeleton
- nucleus
- mainly cytoplasmic & weakly nuclear
- in CNS, it is expressed in the perikaryon & proximal portion of neuronal processes
Alternative splicing: named isoforms=2
Expression:
- brain specific
- strong expression in the hippocampus, neuron-rich dendate granule cells, & pyramidal cell layers
- highly expressed in neurons of the cerebral cortex
- also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, & basal ganglia
- no expression in muscle cells
General
syntrophin (dystrophin-associated protein)
Properties
SIZE: entity length = 517 aa
MW = 58 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: PDZ domain
NAME: PDZ domain
SITE: 57-140
DHR domain
PH domain {283-390}
Database Correlations
OMIM 608714
UniProt Q9NSN8
Pfam PF00595
Entrez Gene 54212
Kegg hsa:54212
References
- UniProt :accession Q9NSN8
- Entrez Gene :accession 54212