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beta-1-syntrophin; 59 kD dystrophin-associated protein A1 basic component 1; DAPA1B; Tax interaction protein 43; TIP-43; syntrophin-2; BSYN2 (SNTB1, SNT2B1)
Function:
- adapter protein that binds to & probably organizes the subcellular localization of a variety of membrane proteins
- may link various receptors to the actin cytoskeleton & the dystrophin glycoprotein complex
- phosphorylated by CaM-kinase 2 (putative)
- interacts with other members of the syntrophin family SNTA1 & SNTB2; with Na+ channel proteins SCN4A & SCN5A (putative).
- interacts with dystrophin protein DMD & related proteins DTNA & UTRN
Structure:
- monomer & homodimer (probable)
- the 1st PH domain mediates oligomerization (Ca+2 dependent) (putative)
- the PDZ domain binds to the last 3 or 4 amino acids of ion channels & receptor proteins; association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane
- the SU domain binds calmodulin (Ca+2-dependent) (putative)
- belongs to the syntrophin family
- contains 1 PDZ domain (DHR domain)
- contains 2 PH domains
- contains 1 SU domain (syntrophin unique)
Compartment:
- cell membrane, sarcolemma
- peripheral membrane protein; cytoplasmic side (putative)
- cell junction (putative)
- cytoplasm, cytoskeleton
- in skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane & at neuromuscular junctions
Alternative splicing: named isoforms=2
Expression: ubiquitous
Pathology:
- interacts with the viral HTLV-1 TAX protein
General
phosphoprotein
syntrophin (dystrophin-associated protein)
Properties
SIZE: entity length = 538 aa
MW = 58 kD
COMPARTMENT: cytoplasm
MOTIF: alanine-rich region {2-10}
MOTIF: alanine residue (SEVERAL)
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
PH domain {19-298}
MOTIF: Ser phosphorylation site {S87}
PDZ domain
NAME: PDZ domain
SITE: 112-195
Thr phosphorylation site {T214}
Ser phosphorylation site {S219}
Ser phosphorylation site {S236}
PH domain {322-433}
MOTIF: Ser phosphorylation site {S389}
SU {482-538}
MOTIF: binding site
SITE: 518-538
FOR-BINDING-OF: calmodulin
Database Correlations
OMIM 600026
UniProt Q13884
PFAM correlations
Entrez Gene 6641
Kegg hsa:6641
References
- OMIM :accession 600026
- Entrez Gene :accession 6641
- UniProt :accession Q13884