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alpha-1-syntrophin; 59 kD dystrophin-associated protein A1 acidic component 1; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; TACIP1; syntrophin-1 (SNTA1 SNT1)

Function: - adapter protein that binds to & probably organizes the subcellular localization of a variety of membrane proteins - may link various receptors to the actin cytoskeleton & the extracellular matrix via the dystrophin glycoprotein complex - plays a role in synapse formation & in organization of UTRN & acetylcholine receptors at the neuromuscular synapse - binds to phosphatidylinositol 4,5-biphosphate (putative) - phosphorylated by CaM-kinase 2; phosphorylation may inhibit interaction with DMD (putative) - interacts with the other members of the syntrophin family SNTB1 & SNTB2; SGCG & SGCA of dystrophin glycoprotein complex; NOS1; GRB2; the Na+ channel proteins SCN4A & SCN5A; F-actin & calmodulin (putative) - interacts with dystrophin protein DMD & related proteins DTNA & UTRN & with MAPK12, TGFA & GA Structure: - monomer & homodimer - the 1st PH domain mediates oligomerization (Ca+2-dependent), & association with phosphatidylinositol 4,5-biphosphate (putative) - the PDZ domain binds to the last 3 or 4 amino acids of ion channels & receptor proteins; association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane - the SU domain binds calmodulin (Ca+2-dependent) - belongs to the syntrophin family - contains 1 PDZ domain (DHR domain) - contains 2 PH domains - contains 1 SU domain (syntrophin unique) Compartment: - cell membrane, sarcolemma - peripheral membrane protein; cytoplasmic side (putative) - cell junction (putative) - cytoplasm, cytoskeleton - in skeletal muscle, localizes at the cytoplasmic side of the sarcolemmal membrane & at neuromuscular junctions Expression: - high expression in skeletal muscle & heart - low expression in brain, pancreas, liver, kidney & lung - not detected in placenta

General

phosphoprotein syntrophin (dystrophin-associated protein)

Properties

SIZE: entity length = 505 aa MW = 54 kD COMPARTMENT: cytoplasm MOTIF: PH domain {6-269} MOTIF: PDZ domain NAME: PDZ domain SITE: 87-170 Ser phosphorylation site {S189} Ser phosphorylation site {S193} PH domain {293-401} SU {449-505} MOTIF: binding site SITE: 483-505 FOR-BINDING-OF: calmodulin

Database Correlations

OMIM 601017 MORBIDMAP 601017 UniProt Q13424 PFAM correlations Entrez Gene 6640 Kegg hsa:6640

References

  1. UniProt :accession Q13424
  2. OMIM :accession 601017
  3. Entrez Gene :accession 6640