Search
7SK SNRNP complex
Function:
- mediates ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling
Structure:
- subunits: composed of P-TEFb (CDK9 & CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins & 7SK & U6 snRNAs
General
molecular complex
Properties
SUBUNITS: cyclin-dependent kinase-9 (CDK9)
STATE: active state
MOTIF: kinase domain
SITE: 19-315
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 25-33
ATP-binding site
NAME: ATP-binding site
SITE: 48-48
aspartate residue {D149}
Thr phosphorylation site {T186}
cyclin T1
COMPARTMENT: cell nucleus
CELL-CYCLE: G1
MOTIF: cyclin box
FOR-BINDING-OF: cyclin-dependent kinase
coiled coil {379-430}
PEST region
SITE: 709-726
protein HEXIM1
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S97}
Ser phosphorylation site {S98}
basic region {150-177}
P-TEFb interaction {202-205}
basic region {210-250}
coiled coil {283-349}
MOTIF: mediates interaction with CCNT1 {286-314}
ESR1 inhibition {310-355}
protein HEXIM2
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S51}
Ser phosphorylation site {S53}
P-TEFb interaction {140-143}
coiled coil {207-277}
CCNT1, HEXIM1 & HEXIM2 interaction {226-286}
BIN3 domain-containing protein 1
MOTIF: glycine-rich region {25-161}
MOTIF: Ser phosphorylation site {S60}
Ser phosphorylation site {S69}
Ser phosphorylation site {S175}
Thr phosphorylation site {T213}
Ser phosphorylation site {S217}
BIN3 {574-683}
MOTIF: Tyr phosphorylation site {Y661}
squamous cell carcinoma antigen recognized by T-cells 3
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: coiled coil {21-46}
coiled coil {82-110}
MOTIF: glutamate-rich region {89-92}
MOTIF: glutamate residue (SEVERAL)
HAT {126-158}
HAT {164-195}
HAT {201-237}
HAT {242-275}
HAT {324-356}
HAT {359-391}
NAME
:SITE RANGE
:LOW 394
:HIGH 430
:NAME "HAT"
HAT {487-520}
coiled coil {559-619}
nuclear localization {600-670}
MOTIF: nuclear translocation signal {601-617}
lysine-rich region {612-616}
MOTIF: lysine residue (SEVERAL)
RNP motif
NAME: RNP motif
SITE: 704-782
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
RNP motif
NAME: RNP motif
SITE: 801-878
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
7SK-SNRNA
U6-snRNA
MOTIF: inverted GTP 5' cap structure
References
UniProt :accession Q96MH2
Components
BIN3 domain-containing protein 1; Bin3 homolog, bicoid-interacting protein 3 homolog (BCDIN3, MEPCE)
cyclin T1 (CCNT1)
cyclin-dependent kinase-9 (CDK9, serine/threonine protein kinase PITALRE, CDC2L4)
protein HEXIM1 (hexamethylene bis-acetamide-inducible protein 1, cardiac lineage protein 1, estrogen down-regulated gene 1 protein, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1)
protein HEXIM2 (hexamethylene bis-acetamide-inducible protein 2, HEXIM2)
squamous cell carcinoma antigen recognized by T-cells 3 (SART-3, hSART-3, Tat-interacting protein of 110 kD, Tip110, SART3, KIAA0156, TIP110)
U6-snRNA