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synaptosomal-associated protein 23; SNAP-23; vesicle-membrane fusion protein SNAP-23 (SNAP23)
Function:
- essential component of the high affinity receptor for the general membrane fusion machinery
- regulator of transport vesicle docking & fusion
- binds simultaneously to SNAPIN & SYN4
- found in a complex with VAMP8 & STX4 in pancreas (putative)
- binds tightly to multiple syntaxins & synaptobrevins/VAMPs
- found in a complex with VAMP8 & STX1A
Structure:
- belongs to the SNAP-25 family
- contains 2 t-SNARE coiled-coil homology domains
Compartment:
- cell membrane, peripheral membrane protein
- cell junction, synapse, synaptosome
- mainly localized to the plasma membrane
Alternative splicing: named isoforms=2; SNAP-23a, SNAP-23b
Expression:
- ubiquitous
- highest levels found in placenta
General
phosphoprotein
synaptosomal-associated protein (SNAP)
Properties
SIZE: entity length = 211 aa
MW = 23 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S6}
SNARE motif {14-76}
MOTIF: Ser phosphorylation site {S20}
Ser phosphorylation site {S34}
Thr phosphorylation site {T102}
Ser phosphorylation site {S110}
SNARE motif {146-208}
Database Correlations
OMIM 602534
UniProt O00161
PFAM correlations
Entrez Gene 8773
Kegg hsa:8773
References
- UniProt :accession O00161
- OMIM :accession 602534