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zinc finger protein SNAI1; protein snail homolog 1; protein sna (SNAI1, SNAH)
Function:
- seems to be involved in embryonic mesoderm formation
- binds to 3 E-boxes of the E-cadherin gene promoter & represses its transcription
Structure:
- belongs to the snail C2H2-type Zn+2-finger protein family
- contains 4 C2H2-type Zn+2 fingers
Compartment:
- nucleus (putative)
Expression:
- expressed in a variety of tissues
- highest expression in kidney
Comparative biology:
- in Drosophila, required for mesoderm formation
- acts as boundary repressor by downregulating expression of ectodermal genes in mesoderm
General
C2H2 type zinc finger protein
phosphoprotein
snail protein homolog
Properties
SIZE: entity length = 264 aa
MW = 29 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S92}
Zn finger C2H2-type
SITE: 154-176
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 178-202
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 208-230
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 236-259
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 604238
UniProt O95863
Pfam PF00096
Entrez Gene 6615
Kegg hsa:6615
References
- UniProt :accession O95863
- OMIM :accession 604238
- Entrez Gene :accession 6615