SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; global transcription activator SNF2L2; ATP-dependent helicase SMARCA2; SNF2-alpha; protein brahma homolog; hBRM; BRG1-associated factor 190B; BAF190B (SMARCA2, BAF190B, BRM, SNF2A, SNF2L2)

Function: - transcriptional coactivator - cooperates with nuclear hormone receptors to potentiate transcriptional activation - also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex - phosphorylated upon DNA damage, probably by ATM or ATR - component of the BAF complex - component of the npBAF complex & the nBAF complex, stem/progenitor & post-mitotic chromatin remodeling complexes - component of the WINAC complex - binds TOPBP1 - interacts with PHF10/BAF45A (putative) Structure: - belongs to the SNF2/RAD54 helicase family - contains 1 bromo domain - contains 1 helicase ATP-binding domain - contains 1 helicase C-terminal domain - contains 1 HSA domain Compartment: nucleus Alternative splicing: named isoforms=2; long, short

General

phosphoprotein SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily A

Properties

SIZE: entity length = 1590 aa MW = 181 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S175} glutamine-rich region {216-238} MOTIF: glutamine residue (SEVERAL) glutamine-rich region {245-253} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S329} HSA {436-508} arginine-rich region {559-562} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S591} glutamate-rich region {643-650} MOTIF: glutamate residue (SEVERAL) helicase NAME: helicase SITE: 736-901 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 749-756 DEAD/H box NAME: DEAD/H box SITE: 851-854 Ser phosphorylation site {S956} Helicase C-terminal {1054-1216} glutamate-rich region {1297-1301} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S1377} Ser phosphorylation site {S1410} Ser phosphorylation site {S1418} bromodomain {1419-1489} MOTIF: Ser phosphorylation site {S1419} Ser phosphorylation site {S1512} Ser phosphorylation site {S1516} glutamate-rich region {1518-1529} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S1528} Ser phosphorylation site {S1568} Ser phosphorylation site {S1572} Ser phosphorylation site {S1582} Ser phosphorylation site {S1585} Thr phosphorylation site {T1587}

Database Correlations

OMIM 600014 UniProt P51531 PFAM correlations Entrez Gene 6595 Kegg hsa:6595

References

UniProt :accession P51531