small nuclear ribonucleoprotein associated protein N (SmN) [tissue-specific slicing factor] (SnRPN)

The SmN protein is closely related to the constitutively expressed RNA splicing protein SmB, but is expressed only in brain & heart tissue. It is a polymorphic protein monoallelically expressed in fetal brain & heart & in adult brain. Analysis of maternal DNA & SmN cDNA indicate that the maternal allele of SmN is not expressed in fetal brain & heart. Mice which lack expression of SmN die shortly after birth suggesting a critical role for this protein possibly in the regulation of neuronal- specific alternative splicing events.

Related

small nuclear ribonucleoprotein polypeptide SmN gene SMN complex

Properties

COMPARTMENT: cell nucleus MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid

Database Correlations

OMIM 182279 UniProt P63162