Search
SMAD protein
Classification:
- receptor regulated SMADs (R-SSMADs): SMAD-1, SMAD-2, SMAD-3, SMAD-5, SMAD-8
- inhibitory SMADs (I-SMADs): SMAD-6 & SMAD-7
- common SMAD (co-SMAD): SMAD-4
Function:
- role in signal transduction by TGF-beta family proteins & bmp proteins
- DNA binding proteins interacting with SMADs include:
- foxH1
- mixer
- c-jun
- lef-1/tcf
- cbfa1, cbfa3
- vdr
- oaz
- hoxc8
- regulated by ubiquitin-proteasomal pathway
Structure:
- related to MAD (mothers against decapentaplegic) in Drosophila & Sma in C elegans.
Specific
smad induced genes/smad gene targets
SMAD1/MADH1; mothers against decapentaplegic homolog 1; mothers against DPP homolog 1; MAD homolog 1; Mad-related protein 1; SMAD family member 1; SMAD 1; smad1; hSMAD1; transforming growth factor-beta-signaling protein 1; BSP-1; JV4-1; dwarfin A (SMAD1, BSP1, MADH1, MADR1)
SMAD2/MADH2; mothers against decapentaplegic homolog 2; mothers against DPP homolog 2; MAD homolog 2; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; smad2; hSMAD2; JV18-1 (SMAD2, MADH2, MADR2)
SMAD3/MADH3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; MAD homolog 3; Mad3; hMAD-3; SMAD family member 3; SMAD 3; smad3; hSMAD3; JV15-2 (SMAD3, MADH3)
SMAD4/MADH4; mothers against decapentaplegic homolog 4; mothers against DPP homolog 4; MAD homolog 4; SMAD family member 4; SMAD 4; smad4; hSMAD4; deletion target in pancreatic carcinoma 4 (SMAD4, DPC4, MADH4)
SMAD5/MADH5; mothers against decapentaplegic homolog 5; mothers against DPP homolog 5; MAD homolog 5; SMAD family member 5; SMAD 5; smad5; hsmad5; JV5-1; dwarfin-C (SMAD5, MADH5)
SMAD6/MADH6; mothers against decapentaplegic homolog 6; mothers against DPP homolog 6; MAD homolog 6; SMAD family member 6; SMAD 6; smad6; hSMAD6 (SMAD6, MADH6)
SMAD7/MADH7; mothers against decapentaplegic homolog 7; mothers against DPP homolog 7; MAD homolog 7; SMAD family member 7; SMAD 7; smad7; hSMAD7; mothers against decapentaplegic homolog 8; mothers against DPP homolog 8; MAD homolog 8 (SMAD7, MADH7, MADH8)
SMAD9/MADH9; mothers against decapentaplegic homolog 9; mothers against DPP homolog 9; MAD homolog 9; SMAD family member 9; SMAD 9; smad9; Madh6 (SMAD9, MADH6, MADH9)
General
other protein
Figures/Diagrams
TGF-beta/BMP signaling
Properties
MOTIF: MH1 domain {N-TERMINUS}
proline-rich region
MOTIF: proline residue (SEVERAL)
MH2 domain {C-TERMINUS}
References
- Derynck R et al
Nomenclature: vertebrate mediators of TGFbeta family signals.
Cell 87:173, 1996
PMID: 8861901
- Izzi L & Attisano L
Regulation of the TGFbeta signalling pathway by
ubiquitin-mediated degradation.
Oncogene 23:2071-8, 2004
PMID: 15021894