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SMAD5/MADH5; mothers against decapentaplegic homolog 5; mothers against DPP homolog 5; MAD homolog 5; SMAD family member 5; SMAD 5; smad5; hsmad5; JV5-1; dwarfin-C (SMAD5, MADH5)
Function:
- transcriptional modulator activated by BMP type 1 receptor kinase
- SMAD5 is a receptor-regulated SMAD (R-SMAD)
- phosphorylated on Ser by BMP type 1 receptor kinase
- ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1
- may form trimers with the co-SMAD SMAD4
- interacts with PEBP2-alpha subunit & SMURF1
- interacts with SUV39H1 & SUV39H2
- interacts (via MH2 domain) with LEMD3
Structure:
- belongs to the dwarfin/SMAD family
- contains 1 MH1 (MAD homology 1) domain
- contains 1 MH2 (MAD homology 2) domain
Compartment:
- cytoplasm, nucleus
- cytoplasmic in the absence of ligand
- migrates to the nucleus when complexed with SMAD4
Expression:
- ubiquitous
General
phosphoprotein
SMAD protein
Properties
SIZE: entity length = 465 aa
MW = 52 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
MH1 domain {13-137}
MOTIF: lysine-rich region {40-46}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S133}
MH2 domain {271-465}
MOTIF: Ser phosphorylation site {S462}
Ser phosphorylation site {S463}
Ser phosphorylation site {S465}
References
- UniProt :accession Q99717
- Derynck R et al
Nomenclature: vertebrate mediators of TGFbeta family signals.
Cell 87:173, 1996
PMID: 8861901
Databases & Figures
OMIM 603110
UniProt Q99717
PFAM correlations
Entrez Gene 4090
Kegg hsa:4090
TGF-beta/BMP signaling