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sarcolemmal membrane-associated protein (sarcolemmal-associated protein, SLMAP, KIAA1601, SLAP, UNQ1847/PRO3577)
Function:
1) role in myoblast fusion
2) interacts with myosin
Structure:
1) homodimer
2) belongs to the SLMAP family
3) contains 1 FHA domain
Compartment:
- cell membrane, sarcolemma
- distributed in the transverse tubules & near the junctional sarcoplasmic reticulum
- detected along the Z-lines & M-lines in cardiomyocytes
- localizes to the centrosomes (microtubule-dependent)
Alternative splicing: named isoforms=8
General
membrane protein
Properties
SIZE: MW = 95 kD
entity length = 828 aa
COMPARTMENT: cellular membrane
MOTIF: Necessary for targeting to centrosomes {1-163}
MOTIF: forkhead-associated (FHA) domain {28-85}
coiled coil {167-202}
coiled coil {230-388}
coiled coil {477-799}
transmembrane domain {803-823}
Database Correlations
OMIM 602701
UniProt Q14BN4
PFAM correlations
References
UniProt :accession Q14BN4