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SLIT & NTRK-like protein 1 (leucine-rich repeat-containing protein 12, SLITRK1, KIAA1910, LRRC12, UNQ233/PRO266)
Function:
- enhances neuronal dendrite outgrowth
Structure:
- belongs to the SLITRK family
- contains 13 LRR repeats (leucine-rich repeats)
Compartment: membrane
Expression:
- expressed predominantly in cerebral cortex, frontal lobe
- at 20 weeks of gestation, expressed in multiple brain regions, including developing neo-cortical plate, subplate zone, striatum, globus pallidus, thalamus & subthalamus
Pathology:
- expressed in some astrocytic brain tumors, astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas, primitive neuroectodermal tumors
- defects in SLITRK1 may be a cause of Gilles de la Tourette syndrome
General
membrane protein
SLIT & NTRK-like protein (SLITRK)
Properties
SIZE: MW = 78 kD
entity length = 696 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-17}
leucine-rich repeat
SITE: 57-80
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 81-104
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 105-128
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 130-152
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 153-176
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 178-200
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 214-237
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 374-397
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 399-421
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 423-445
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 446-469
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 470-493
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 495-517
MOTIF: leucine residue (SEVERAL)
transmembrane domain {623-643}
Database Correlations
OMIM 137580
UniProt Q96PX8
Pfam PF00560
References
UniProt :accession Q96PX8