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Slit homolog 1 protein; Slit-1; multiple EGF-like domains protein 4 (SLIT1, KIAA0813, MEGF4, SLIL1)
Function:
- thought to act as molecular guidance cue in cell migration
- function appears to be mediated by interaction with roundabout homolog receptors
- during neural development involved in axonal navigation at the ventral midline of the neural tube & projection of axons to different regions (putative)
- SLIT1 & SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb
- interacts with ROBO1 & GREM1 (putative)
Structure:
- contains 1 CTCK (C-terminal cystine knot-like) domain
- contains 9 EGF-like domains
- contains 1 laminin G-like domain
- contains 20 LRR repeats (leucine-rich repeats)
- contains 4 LRRCT domains
- contains 4 LRRNT domains
Compartment: secreted (putative)
Alternative splicing: named isoforms=2
Expression:
- predominantly expressed in adult forebrain
- expressed in fetal brain, lung & kidney
General
leucine-rich repeat-containing protein (LRRC)
multiple epidermal growth factor like domains (protein)
slit homolog protein
Properties
SIZE: entity length = 1534 aa
MW = 168 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-33}
LRRNT {34-61}
leucine-rich repeat
SITE: 62-83
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N72}
leucine-rich repeat
SITE: 86-107
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 110-131
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 134-155
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 158-179
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 182-203
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N192}
LRRCT 1 {215-265}
LRRNT 2 {273-309}
MOTIF: cysteine residue {C286}
MODIFICATION: cysteine residue {C295}
cysteine residue {C295}
MODIFICATION: cysteine residue {C286}
leucine-rich repeat
SITE: 310-331
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 334-355
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 358-379
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 382-403
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 406-427
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N406}
LRRCT 2 {439-489}
MOTIF: cysteine residue {C443}
MODIFICATION: cysteine residue {C466}
cysteine residue {C445}
MODIFICATION: cysteine residue {C487}
cysteine residue {C466}
MODIFICATION: cysteine residue {C443}
cysteine residue {C487}
MODIFICATION: cysteine residue {C445}
LRRNT 3 {504-540}
MOTIF: cysteine residue {C513}
MODIFICATION: cysteine residue {C519}
cysteine residue {C517}
MODIFICATION: cysteine residue {C526}
cysteine residue {C519}
MODIFICATION: cysteine residue {C513}
cysteine residue {C526}
MODIFICATION: cysteine residue {C517}
leucine-rich repeat
SITE: 541-562
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 566-587
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N571}
leucine-rich repeat
SITE: 590-611
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 614-635
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N630}
leucine-rich repeat
SITE: 638-659
MOTIF: leucine residue (SEVERAL)
LRRCT 3 {671-721}
MOTIF: cysteine residue {C675}
MODIFICATION: cysteine residue {C698}
cysteine residue {C677}
MODIFICATION: cysteine residue {C719}
cysteine residue {C698}
MODIFICATION: cysteine residue {C675}
cysteine residue {C719}
MODIFICATION: cysteine residue {C677}
LRRNT 4 {725-761}
leucine-rich repeat
SITE: 762-783
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N762}
leucine-rich repeat
SITE: 785-806
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N801}
N-glycosylation site {N806}
leucine-rich repeat
SITE: 809-830
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 833-854
MOTIF: leucine residue (SEVERAL)
LRRCT 4 {866-916}
EGF domain {927-962}
MOTIF: cysteine residue {C929}
MODIFICATION: cysteine residue {C940}
cysteine residue {C934}
MODIFICATION: cysteine residue {C950}
cysteine residue {C940}
MODIFICATION: cysteine residue {C929}
cysteine residue {C950}
MODIFICATION: cysteine residue {C934}
cysteine residue {C952}
MODIFICATION: cysteine residue {C961}
cysteine residue {C961}
MODIFICATION: cysteine residue {C952}
EGF domain {964-1003}
MOTIF: cysteine residue {C968}
MODIFICATION: cysteine residue {C979}
cysteine residue {C973}
MODIFICATION: cysteine residue {C991}
cysteine residue {C979}
MODIFICATION: cysteine residue {C968}
cysteine residue {C991}
MODIFICATION: cysteine residue {C973}
cysteine residue {C993}
MODIFICATION: cysteine residue {C1002}
cysteine residue {C1002}
MODIFICATION: cysteine residue {C993}
EGF domain {1005-1041}
MOTIF: cysteine residue {C1009}
MODIFICATION: cysteine residue {C1020}
cysteine residue {C1014}
MODIFICATION: cysteine residue {C1029}
cysteine residue {C1020}
MODIFICATION: cysteine residue {C1009}
N-glycosylation site {N1026}
cysteine residue {C1029}
MODIFICATION: cysteine residue {C1014}
cysteine residue {C1031}
MODIFICATION: cysteine residue {C1040}
cysteine residue {C1040}
MODIFICATION: cysteine residue {C1031}
EGF domain {1043-1081}
MOTIF: cysteine residue {C1047}
MODIFICATION: cysteine residue {C1060}
cysteine residue {C1054}
MODIFICATION: cysteine residue {C1069}
cysteine residue {C1060}
MODIFICATION: cysteine residue {C1047}
cysteine residue {C1069}
MODIFICATION: cysteine residue {C1054}
cysteine residue {C1071}
MODIFICATION: cysteine residue {C1080}
N-glycosylation site {N1079}
cysteine residue {C1080}
MODIFICATION: cysteine residue {C1071}
EGF domain {1083-1119}
MOTIF: cysteine residue {C1087}
MODIFICATION: cysteine residue {C1098}
cysteine residue {C1092}
MODIFICATION: cysteine residue {C1107}
cysteine residue {C1098}
MODIFICATION: cysteine residue {C1087}
cysteine residue {C1107}
MODIFICATION: cysteine residue {C1092}
cysteine residue {C1109}
MODIFICATION: cysteine residue {C1118}
cysteine residue {C1118}
MODIFICATION: cysteine residue {C1109}
EGF domain {1127-1163}
MOTIF: cysteine residue {C1131}
MODIFICATION: cysteine residue {C1142}
cysteine residue {C1136}
MODIFICATION: cysteine residue {C1151}
cysteine residue {C1142}
MODIFICATION: cysteine residue {C1131}
cysteine residue {C1151}
MODIFICATION: cysteine residue {C1136}
cysteine residue {C1153}
MODIFICATION: cysteine residue {C1162}
cysteine residue {C1162}
MODIFICATION: cysteine residue {C1153}
Laminin G-like {1166-1339}
MOTIF: N-glycosylation site {N1189}
N-glycosylation site {N1259}
N-glycosylation site {N1306}
cysteine residue {C1313}
MODIFICATION: cysteine residue {C1339}
cysteine residue {C1339}
MODIFICATION: cysteine residue {C1313}
EGF domain {1340-1374}
MOTIF: cysteine residue {C1342}
MODIFICATION: cysteine residue {C1352}
cysteine residue {C1347}
MODIFICATION: cysteine residue {C1362}
cysteine residue {C1352}
MODIFICATION: cysteine residue {C1342}
cysteine residue {C1362}
MODIFICATION: cysteine residue {C1347}
cysteine residue {C1364}
MODIFICATION: cysteine residue {C1373}
cysteine residue {C1373}
MODIFICATION: cysteine residue {C1364}
EGF domain {1377-1413}
MOTIF: cysteine residue {C1381}
MODIFICATION: cysteine residue {C1391}
cysteine residue {C1386}
MODIFICATION: cysteine residue {C1401}
cysteine residue {C1391}
MODIFICATION: cysteine residue {C1381}
cysteine residue {C1401}
MODIFICATION: cysteine residue {C1386}
cysteine residue {C1403}
MODIFICATION: cysteine residue {C1412}
cysteine residue {C1412}
MODIFICATION: cysteine residue {C1403}
EGF domain {1418-1454}
MOTIF: cysteine residue {C1422}
MODIFICATION: cysteine residue {C1432}
cysteine residue {C1427}
MODIFICATION: cysteine residue {C1442}
cysteine residue {C1432}
MODIFICATION: cysteine residue {C1422}
cysteine residue {C1442}
MODIFICATION: cysteine residue {C1427}
cysteine residue {C1444}
MODIFICATION: cysteine residue {C1453}
cysteine residue {C1453}
MODIFICATION: cysteine residue {C1444}
C-terminal cystine knot {1459-1534}
MOTIF: cysteine residue {C1459}
MODIFICATION: cysteine residue {C1498}
cysteine residue {C1477}
MODIFICATION: cysteine residue {C1512}
cysteine residue {C1488}
MODIFICATION: cysteine residue {C1528}
cysteine residue {C1492}
MODIFICATION: cysteine residue {C1530}
cysteine residue {C1498}
MODIFICATION: cysteine residue {C1459}
cysteine residue {C1512}
MODIFICATION: cysteine residue {C1477}
cysteine residue {C1528}
MODIFICATION: cysteine residue {C1488}
cysteine residue {C1530}
MODIFICATION: cysteine residue {C1492}
Database Correlations
OMIM 603742
UniProt O75093
PFAM correlations
Entrez Gene 6585
Kegg hsa:6585
References
UniProt :accession O75093