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solute carrier family 21 member 6; solute carrier organic anion transporter family member 1B1; liver-specific organic anion transporter 1; LST-1; OATP-C; Na+-independent organic anion-transporting polypeptide 2; OATP-2 (SLCO1B1, LST1, OATP1B1, OATP2, OATPC, SLC21A6)
Function:
- mediates Na+-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine & triiodothyronine
- may play a role in the clearance of bile acids & organic anions from the liver
Structure:
- belongs to the organo anion transporter (TC 2.A.60) family
- contains 1 Kazal-like domain
Compartment:
- basolateral cell membrane
- detected in basolateral membranes of hepatocytes
Expression:
- highly expressed in liver
- not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon or leukocytes
Pathology:
- myopathy related to SLCO1B1 variant
General
glycoprotein
organic anion transporting polypeptide (OATP)
solute carrier family 21 (SLC21, SLC21A)
transmembrane 7c protein
Properties
SIZE: entity length = 691 aa
MW = 76 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {97-117}
N-glycosylation site {N130}
N-glycosylation site {N134}
transmembrane domain {207-227}
transmembrane domain {259-279}
transmembrane domain {336-356}
transmembrane domain {376-396}
transmembrane domain {410-430}
N-glycosylation site {N432}
Kazal-type serine protease inhibitor domain {453-508}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
N-glycosylation site {N503}
FOR-BINDING-OF: serine protease
N-glycosylation site {N516}
transmembrane domain {575-595}
N-glycosylation site {N617}
Database Correlations
OMIM 604843
UniProt Q9Y6L6
PFAM correlations
Entrez Gene 10599
Kegg hsa:10599
References
- UniProt :accession Q9Y6L6
- SeattleSNPs
http://pga.gs.washington.edu/data/slco1b1/