Na+/hydrogen exchanger 9; Na+/H+ exchanger 9; NHE-9; solute carrier family 9 member 9 (SLC9A9, NHE9, Nbla00118)

Function: - may act in electroneutral exchange of protons for Na⁺ across membranes - involved in the effusion of Golgi luminal H⁺ in exchange for cytosolic cations - involved in organelle ion homeostasis by contributing to maintenance of the acidic pH of the Golgi & post-Golgi compartments Structure: - belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family Compartment: - late endosome membrane; multi-pass membrane protein Expression: - ubiquitously expressed in all tissues tested - expressed at highest levels in heart & skeletal muscle, -lesser expression in placenta, kidney, & liver - expressed in brain, medulla oblongata & spinal cord Pathology: - chromosomal inversion inv(3)(p14:q21) involving DOCK3 & SLC9A9 associated with ADHD - defects in SLC9A9 are a cause of susceptibility to autism type 16

General

Na+/H+ antiporter solute carrier family 9 (SLC9, SLC9A) transmembrane 13 protein

Properties

SIZE: entity length = 645 aa MW = 73 kD COMPARTMENT: plasma membrane MOTIF: transmembrane domain {21-41} transmembrane domain {46-66} N-glycosylation site {N96} transmembrane domain {127-147} transmembrane domain {165-185} transmembrane domain {204-224} transmembrane domain {236-256} transmembrane domain {278-298} transmembrane domain {302-322} transmembrane domain {323-343} transmembrane domain {365-385} transmembrane domain {387-407} transmembrane domain {430-450} transmembrane domain {466-486}

Database Correlations

OMIM correlations UniProt Q8IVB4 Pfam PF00999 Entrez Gene 285195 Kegg hsa:285195

References

UniProt :accession Q8IVB4