Na+/H+ exchanger NHE3 (apical epithelial Na+/H+ exchanger, solute carrier family 9 isoform A3, SLC9A3)

Function: - role in pH regulation - elimination of acids generated by active metabolism or adverse environmental conditions - major proton extruding system driven by the inward Na⁺ chemical gradient - role in signal transduction - binds SLC9A3R1 & SLC9A3R2 - interacts with SHANK2 - phosphorylated by PKA, which inhibits activity Structure: - belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family Compartment: membrane

General

glycoprotein solute carrier family 9 (SLC9, SLC9A) transmembrane 10 protein

Properties

SIZE: MW = 93 kD entity length = 834 aa COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-79} MOTIF: hydrophobic domain {13-79} hydrophobic domain {55-73} transmembrane domain {80-99} exoplasmic loop {100-112} transmembrane domain {113-133} cytoplasmic loop {134-139} transmembrane domain {140-160} exoplasmic loop {161-180} transmembrane domain {181-202} cytoplasmic loop {203-210} transmembrane domain {211-232} exoplasmic loop {233-252} MOTIF: N-glycosylation site {N241} transmembrane domain {253-274} cytoplasmic loop {275-290} transmembrane domain {291-309} exoplasmic loop {310-340} MOTIF: N-glycosylation site {N326} transmembrane domain {341-362} cytoplasmic loop {363-369} transmembrane domain {370-390} exoplasmic loop {391-435} MOTIF: hydrophobic domain {406-426} transmembrane domain {436-456} cytoplasmic domain {457-834}

Database Correlations

OMIM 182307 UniProt P48764 Pfam PF00999 Entrez Gene 6550 Kegg hsa:6550