Na+ & chloride-dependent GABA transporter 1; GAT-1; solute carrier family 6 member 1 (SLC6A1, GABATR, GABT1, GAT1)

Function: - terminates the action of GABA by its high affinity - Na⁺-dependent reuptake into presynaptic terminals - interacts with MPP5 (putative) Structure: - the PDZ domain-binding motif is involved in the - interaction with MPP5 - belongs to the Na⁺:neurotransmitter symporter (SNF) family Compartment: - cell membrane - localized at plasma membrane & in a subset of intracellular vesicles - localized at the presynaptic terminals of interneurons Pharmacology: - SLC6A1 is the target of psychomotor stimulants such as amphetamines or cocaine

Properties

SIZE: entity length = 599 aa MW = 67 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-52} transmembrane domain {53-73} exoplasmic loop {74-80} transmembrane domain {81-100} cytoplasmic loop {101-123} transmembrane domain {124-144} exoplasmic loop {145-211} MOTIF: N-glycosylation site {N176} N-glycosylation site {N181} N-glycosylation site {N184} transmembrane domain {212-230} cytoplasmic loop {231-238} transmembrane domain {239-256} exoplasmic loop {257-291} transmembrane domain {292-309} cytoplasmic loop {310-320} transmembrane domain {321-342} exoplasmic loop {343-374} transmembrane domain {375-394} cytoplasmic loop {395-421} transmembrane domain {422-440} exoplasmic loop {441-456} transmembrane domain {457-477} cytoplasmic loop {478-497} transmembrane domain {498-517} exoplasmic loop {518-535} transmembrane domain {536-554} cytoplasmic domain {555-599} MOTIF: PDZ recognition motif NAME: PDZ recognition motif SITE: 597-599 FOR-BINDING-VIA: PDZ domain

Database Correlations

OMIM 137165 UniProt P30531 Pfam PF00209 Entrez Gene 6529