Search
Na+/myo-inositol cotransporter 2 (Na+/myo-inositol cotransporter 2, Na+/glucose cotransporter KST1, Na+-dependent glucose cotransporter, solute carrier family 5 member 11, SLC5A11, KST1, SLGTX, SMIT2)
Function:
- role in the Na+-dependent cotransport of myo-inositol (MI) with a Na+:MI stoichiometry of 2:1
- exclusively responsible for apical myo-inositol transport & absorption in intestine
- also can transport D-chiro-inositol (DCI) but not L-fructose
- exhibits stereospecific cotransport of both D-glucose & D-xylose
- may induce apoptosis through the TNF-alpha, PDCD1 pathway
- may play a role in regulation of myo-inositol concentration in serum, involving reabsorption in proximal renal tubule
Structure:
- belongs to the Na+:solute symporter (SSF) (TC 2.A.21) family
Compartment: membrane
Alternative splicing: named isoforms=4
Expression:
- highest expression in heart, skeletal muscle, kidney, liver & placenta
- weaker expression in brain, colon, spleen, lung & peripheral blood leukocytes
Pathology:
- acts as an autoimmune modifier in systemic lupus erythematosus (SLE) as it is significantly associated with low complement component 4 (C4), anti-Smith antibody, serositis, & alopecia
General
solute carrier family 5 (SLC5, SLC5A)
transmembrane 14e protein
Properties
SIZE: entity length = 675 aa
MW = 74 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-27}
transmembrane domain {28-48}
cytoplasmic loop {49-65}
transmembrane domain {66-88}
exoplasmic loop {89-102}
transmembrane domain {103-123}
cytoplasmic loop {124-135}
transmembrane domain {136-156}
exoplasmic loop {157-180}
transmembrane domain {181-201}
cytoplasmic loop {202-208}
transmembrane domain {209-229}
exoplasmic loop {230-272}
transmembrane domain {273-293}
cytoplasmic loop {294-308}
transmembrane domain {309-329}
exoplasmic loop {330-375}
transmembrane domain {376-396}
cytoplasmic loop {397-418}
transmembrane domain {419-439}
exoplasmic loop {440-446}
transmembrane domain {447-467}
cytoplasmic loop {468-479}
transmembrane domain {480-500}
exoplasmic loop {501-521}
transmembrane domain {522-542}
cytoplasmic loop {543-654}
transmembrane domain {655-674}
exoplasmic domain {675-675}
Database Correlations
UniProt Q8WWX8
Pfam PF00474
Kegg hsa:1155
References
UniProt :accession Q8WWX8