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solute carrier family 29 member 1; equilibrative nucleoside transporter 1; equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; equilibrative NBMPR-sensitive nucleoside transporter; nucleoside transporter, es-type (SLC29A1v ENT1)
Function:
- mediates both influx & efflux of nucleosides across the membrane (equilibrative transporter)
- sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) & is Na+-independent
- higher affinity for adenosine
- inhibited by dipyridamole
Structure:
- glycosylated
- belongs to the SLC29A transporter family
Compartment: membrane
Expression:
- expressed in heart, brain, mammary gland, erythrocytes &
- placenta
- expressed in fetal liver & spleen
General
glycoprotein
solute carrier family 29 (SLC29, SLC29A)
transmembrane 11 protein
Properties
SIZE: entity length = 456 aa
MW = 50 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {2-12}
transmembrane domain {13-29}
exoplasmic loop {30-82}
MOTIF: N-glycosylation site {N48}
transmembrane domain {83-107}
cytoplasmic loop {108-111}
transmembrane domain {112-130}
exoplasmic loop {131-138}
transmembrane domain {139-157}
cytoplasmic loop {158-174}
transmembrane domain {175-199}
exoplasmic loop {200-206}
transmembrane domain {207-227}
cytoplasmic loop {228-291}
MOTIF: Ser phosphorylation site {S254}
transmembrane domain {292-311}
exoplasmic loop {312-323}
transmembrane domain {324-342}
cytoplasmic loop {343-359}
transmembrane domain {360-378}
exoplasmic loop {379-393}
transmembrane domain {394-413}
cytoplasmic loop {414-431}
transmembrane domain {432-452}
exoplasmic domain {453-456}
Database Correlations
OMIM 602193
UniProt Q99808
Pfam PF01733
Entrez Gene 2030
Kegg hsa:2030
References
UniProt :accession Q99808