solute carrier family 27 member 4 (SLC27A4, long-chain fatty acid transport protein 4, fatty acid transport protein 4, FATP-4, ACSVL4, FATP4)

Function: - involved in translocation of long-chain fatty acids across the plasma membrane - principal fatty acid transporter in small intestinal enterocytes - role in the formation of the epidermal barrier - acyl-CoA ligase activity for a) long-chain fatty acids b) very long-chain fatty acids Structure: - belongs to the ATP-dependent AMP-binding enzyme family Compartment: membrane (probable) Expression: - expressed in brain, testis, colon & kidney > heart & liver, small intestine & stomach > peripheral blood leukocytes, bone marrow, skeletal muscle & aorta - expressed in adipose tissue Pathology: - SLC27A4/FATP4-mediated fatty acid uptake is associated with parameters related to: a) insulin resistance b) fatty acid metabolism & homeostasis c) obesity - SLC27A4/FATP4 expression is positively correlated with aquired obesity

General

ligase or synthetase solute carrier family 27 (SLC27, SLC27A) transmembrane 2 protein

Properties

SIZE: MW = 72 kD entity length = 643 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {20-42} transmembrane domain {139-156}

Database Correlations

OMIM 604194 UniProt Q6P1M0 Pfam PF00501 Kegg hsa:1099

References

UniProt :accession Q6P1M0