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chloride anion exchanger; down-regulated in adenoma; protein DRA; solute carrier family 26 member 3 (SLC26A3, DRA)
Function:
- chloride/bicarbonate exchanger
- possible sulfate transporter
- involved in absorption in the colon
- helps mediate electrolyte & fluid absorption
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with PDZK1
Structure:
- belongs to the SLC26A/sulP transporter (TC 2.A.53) family
- contains 1 STAS domain
Compartment: membrane (probable)
Expression:
- intestinal epithlelium
Pathology:
1) expression is significantly decreased in
a) colorectal adenoma
b) adenocarcinoma of the colon
2) defects in SLC26A3 are the cause of congenital chloride diarrhea
General
phosphoprotein
solute carrier family 25 (SLC25, SLC25A)
transmembrane 14 protein
Properties
SIZE: entity length = 764 aa
MW = 85 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {77-97}
transmembrane domain {100-120}
transmembrane domain {125-145}
transmembrane domain {176-196}
transmembrane domain {198-218}
transmembrane domain {259-279}
transmembrane domain {286-306}
transmembrane domain {343-363}
transmembrane domain {375-395}
transmembrane domain {412-432}
transmembrane domain {439-459}
transmembrane domain {470-490}
Thr phosphorylation site {T503}
Ser phosphorylation site {S509}
Tyr phosphorylation site {Y520}
STAS {525-720}
MOTIF: transmembrane domain {644-664}
transmembrane domain {702-722}
Database Correlations
OMIM correlations
UniProt P40879
PFAM correlations
Entrez Gene 1811
Kegg hsa:1811
References
- UniProt :accession P40879
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC26A3