solute carrier family 22 member 18 (SLC22A18, organic cation transporter-like protein 2, imprinted multi-membrane spanning polyspecific transporter-related protein 1, efflux transporter-like protein, tumor-suppressing subchromosomal transferable fragment candidate gene protein 5, tumor-suppressing STF cDNA 5 protein, Beckwith-Wiedemann syndrome chromosome region 1 candidate protein A, p45-Beckwith-Wiedemann region 1 A, p45-BWR1A, solute carrier family 22 member 1-like, BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5)

Function: - transporter of organic cations via proton efflux antiport (putative) - role in transport of chloroquine & quinidine-related compounds in kidney (putative) - interacts with RNF167 Structure: - belongs to the major facilitator superfamily, organic cation transporter family Compartment: - apical cell membrane - localized at the apical membrane surface of renal proximal tubules Expression: - expressed in adult & fetal kidney & liver,& adult colon > heart, brain & lung - expressed in fetal renal proximal tubules (at protein level) Pathology: - defects in SLC22A18 are associated with a) breast cancer b) lung cancer - defects in SLC22A18 are the cause of rhabdomyosarcoma type 1

General

solute carrier family 22 (SLC22, SLC22A) transmembrane 8 protein

Properties

SIZE: MW = 43 kD entity length = 408 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {10-30} transmembrane domain {43-63} transmembrane domain {74-94} transmembrane domain {140-160} transmembrane domain {168-188} transmembrane domain {227-247} transmembrane domain {260-280} transmembrane domain {296-316} transmembrane domain {318-338} transmembrane domain {375-395}

Database Correlations

OMIM correlations MORBIDMAP 602631 UniProt Q96BI1 Pfam PF07690 Kegg hsa:5002

References

UniProt :accession Q96BI1