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excitatory amino acid transporter 1; Na+ dependent glutamate/aspartate transporter 1; GLAST-1; solute carrier family 1 member 3 (SLC1A3, EAAT1, GLAST, GLAST1)
Function:
- transports L-glutamate & also L- & D-aspartate
- essential for terminating postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft
- acts as a symporter by cotransporting Na+
- may be astrocyte/glial glutamate/aspartate transporter in brain
Structure:
- glycosylated
- belongs to the Na+:dicarboxylate (SDF) symporter (TC 2.A.23) family
Compartment: membrane
Expression:
- highly expressed in cerebellum
- also found in frontal cortex, hippocampus & basal ganglia
Pathology:
- defects in SLC1A3 are the cause of episodic ataxia type 6
General
glutamate/aspartate transporter (excitatory amino acid transporter)
solute carrier family 1 (SLC1 SLC1A)
transmembrane 6 protein
Properties
SIZE: entity length = 542 aa
MW = 60 kD
COMPARTMENT: plasma membrane
CELL: neuroglia
MOTIF: cytoplasmic domain {1-47}
transmembrane domain {48-68}
exoplasmic loop {69-90}
transmembrane domain {91-111}
cytoplasmic loop {112-122}
transmembrane domain {123-145}
exoplasmic loop {146-237}
transmembrane domain {238-260}
cytoplasmic loop {261-280}
transmembrane domain {281-302}
exoplasmic loop {303-318}
transmembrane domain {319-340}
cytoplasmic domain {341-542}
MOTIF: Ser phosphorylation site {S512}
ION-PERMEABILITY: Na+
K+
Database Correlations
OMIM 600111
UniProt P43003
Pfam PF00375
Entrez Gene 6507
Kegg hsa:6507
References
- UniProt :accession P43003
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC1A3