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Na+-dependent phosphate transport protein 1; Na+/phosphate cotransporter 1; Na+/PI cotransporter 1; solute carrier family 17 member 1; renal Na+-dependent phosphate transport protein 1; renal Na+-phosphate transport protein 1; renal Na+-dependent phosphate cotransporter 1; Na/Pi-4 (SLC17A1, NPT1)
Function:
- role in resorption of phosphate by the kidney
- role in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane
- interacts with PDZK1 (putative)
Structure:
- belongs to the major facilitator superfamily Na+/anion cotransporter family
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in renal cortex, liver & brain
- not expressed in other tissues
Note: It is uncertain whether Met-1 or Met-3 is the initiator
General
major facilitator superfamily (MFS)
Na+/phosphate cotransporter or renal Na+/phosphate transport protein
solute carrier family 17 (SLC17, SLC17A)
Properties
SIZE: entity length = 467 aa
MW = 51 kD
COMPARTMENT: cellular membrane
MOTIF: N-glycosylation site {N41}
N-glycosylation site {N49}
N-glycosylation site {N58}
transmembrane domain {81-101}
transmembrane domain {119-139}
transmembrane domain {178-198}
transmembrane domain {200-220}
transmembrane domain {257-277}
transmembrane domain {301-321}
transmembrane domain {339-359}
transmembrane domain {365-385}
transmembrane domain {401-421}
transmembrane domain {433-453}
Database Correlations
OMIM 182308
UniProt Q14916
Pfam PF07690
Entrez Gene 6568
References
UniProt :accession Q14916