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natural resistance-associated macrophage protein 2 (NRAMP2, divalent metal transporter 1, DMT1, solute carrier family 11 member 2, SLC11A2, OK/SW-cl20)
Function:
- macrophage-specific membrane transport
- important in metal transport, in particular iron
Structure: belongs to the NRAMP family
Compartment: membrane (probable)
Alternative splicing: named isoforms=2
Expression: expressed at low levels in all tissues analyzed
Pathology:
- defects in SLC11A2 are a cause of hypochromic microcytic anemia
- mutations in SLC11A2 are associated with progressive liver iron overload & normal to moderately elevated serum ferritin levels
General
natural resistance-associated macrophage protein (Nramp)
solute carrier family 11 (SLC11, SLC11A)
Properties
SIZE: MW = 62 kD
entity length = 568 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-69}
transmembrane domain {70-90}
exoplasmic loop {91-96}
transmembrane domain {97-117}
cytoplasmic loop {118-154}
transmembrane domain {155-175}
exoplasmic loop {176-179}
transmembrane domain {180-200}
cytoplasmic loop {201-208}
transmembrane domain {209-229}
exoplasmic loop {230-255}
transmembrane domain {256-276}
cytoplasmic loop {277-301}
transmembrane domain {302-322}
exoplasmic loop {323-360}
MOTIF: N-glycosylation site {N336}
N-glycosylation site {N349}
transmembrane domain {361-381}
cytoplasmic loop {382-408}
transmembrane domain {409-429}
exoplasmic loop {430-440}
transmembrane domain {441-461}
cytoplasmic loop {462-482}
transmembrane domain {483-503}
exoplasmic loop {504-506}
transmembrane domain {507-527}
cytoplasmic domain {528-568}
Database Correlations
OMIM correlations
MORBIDMAP 600523
UniProt P49281
Pfam PF01566
Kegg hsa:4891
References
UniProt :accession P49281