histone RNA hairpin-binding protein (histone stem-loop-binding protein, SLBP, HBP)

Function: 1) binds the stem-loop structure of replication-dependent histone pre-mRNAs 2) contributes to efficient 3' end processing by stabilizing the complex between histone pre-mRNA & U7 small nuclear ribonucleoprotein (snRNP) 3) targeting mature histone mRNA from the nucleus to the cytoplasm & to the translation machinery 4) Stabilizes mature histone mRNA 5) cell-cycle regulation of histone gene expression 6) SLBP/pre-mRNA complex interacts with ZNF473 Compartment: cytoplasm, nucleus, polyribosome-associated Expression: - widely expressed - regulated during the cell cycle, - protein levels increase 10-20 fold in late G1 & decrease at S/G2 border

General

phosphoprotein RNA-binding protein

Properties

SIZE: MW = 31 kD entity length = 270 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Thr phosphorylation site {T62} FOR-PHOSPHORYLATION-BY: cyclin-dependent kinase-1 binding site SITE: 129-198 FOR-BINDING-OF: ribonucleic acid

Database Correlations

OMIM 602422 UniProt Q14493

References

UniProt :accession Q14493