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SKP1-CUL1-F-box protein (SCF) complex; SCF(FBXW11) E3 ligase complex; CF(SKP2) E3 ligase complex
Function:
- mediates ubiquitination & subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction & transcription
- recognizes phosphorylated CDKN1B/p27kip & is involved in regulation of G1/S transition
Structure:
- consists of CUL1, RBX1, SKP1, SKP2, FBXL (FBXL19, FBXL21, FBXW9, FBXW12)
Related
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
General
SCF-type E3 ligase complex
Properties
SUBUNITS: S-phase kinase-associated protein 1
MOTIF: F-box interaction {104-163}
S-phase kinase-associated protein 2
MOTIF: Ser phosphorylation site {S64}
F-box domain {94-140}
Ser phosphorylation site {S179}
leucine-rich repeat
SITE: 180-204
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 210-234
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 258-284
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 286-308
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 309-330
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 334-356
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 359-378
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 380-403
MOTIF: leucine residue (SEVERAL)
cullin 1
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: membrane region
binding site
SITE: 720-720
FOR-BINDING-OF: ubiquitin
RING-box protein 1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S11}
Zn+2-binding site
SITE: 42-42
Zn+2-binding site
SITE: 45-45
RING-finger {53-98}
MOTIF: Zn+2-binding site
SITE: 53-53
Zn+2-binding site
SITE: 56-56
Zn+2-binding site
SITE: 68-68
Zn+2-binding site
SITE: 75-75
Zn+2-binding site
SITE: 77-77
Zn+2-binding site
SITE: 80-80
Zn+2-binding site
SITE: 82-82
Zn+2-binding site
SITE: 83-83
Zn+2-binding site
SITE: 94-94
Zn+2-binding site
SITE: 97-97
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
F-box & leucine-rich repeat protein
MOTIF: F-box domain
leucine-rich repeat
MOTIF: leucine residue (SEVERAL)
cullin-associated NEDD8-dissociated protein 1
COMPARTMENT: cell nucleus
MOTIF: HEAT repeat {2-39}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
HEAT repeat {44-81}
HEAT repeat {83-119}
HEAT repeat {131-165}
HEAT repeat {171-208}
HEAT repeat {210-247}
HEAT repeat {248-282}
HEAT repeat {289-366}
MOTIF: Ser phosphorylation site {S335}
Ser phosphorylation site {S340}
HEAT repeat {370-407}
HEAT repeat {424-467}
HEAT repeat {471-510}
HEAT repeat {515-552}
HEAT repeat {563-602}
HEAT repeat {606-643}
MOTIF: Thr phosphorylation site {T624}
HEAT repeat {646-683}
HEAT repeat {688-725}
HEAT repeat {729-768}
HEAT repeat {770-808}
HEAT repeat {809-845}
HEAT repeat {852-889}
HEAT repeat {890-927}
HEAT repeat {928-960}
HEAT repeat {961-998}
HEAT repeat {1002-1039}
HEAT repeat {1043-1097}
HEAT repeat {1099-1133}
HEAT repeat {1140-1189}
References
- UniProt :accession P34991
- UniProt :accession Q13309
Components
cullin homolog 1 (CUL-1)
cullin-associated NEDD8-dissociated protein 1; cullin-associated & neddylation-dissociated protein 1; TBP-interacting protein of 120 kD A; TBP-interacting protein 120A; p120 CAND1 (CAND1, KIAA0829, TIP120, TIP120A)
F-box & leucine-rich repeat protein
RING-box protein 1; Rbx1; regulator of cullins 1; RING finger protein 75; protein ZYP (RBX1 RNF75 ROC1)
S-phase kinase-associated protein 1; cyclin-A/CDK2-associated protein p19; p19skp1; p19A; RNA polymerase II elongation factor-like protein; organ of corti protein 2; OCP-2; organ of corti protein II; OCP-II; transcription elongation factor B; SIII (SKP1, EMC19, OCP2, SKP1A, TCEB1L)
S-phase kinase-associated protein 2; F-box protein Skp2; cyclin-A/CDK2-associated protein p45; p45skp2; F-box/LRR-repeat protein 1 (SKP2 FBXL1)