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S-phase kinase-associated protein 1; cyclin-A/CDK2-associated protein p19; p19skp1; p19A; RNA polymerase II elongation factor-like protein; organ of corti protein 2; OCP-2; organ of corti protein II; OCP-II; transcription elongation factor B; SIII (SKP1, EMC19, OCP2, SKP1A, TCEB1L)
Function:
- component of the SCF complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction & transcription
- in the SCF complex, serves as an adapter that links the F-box protein to CUL1
- interacts with the cyclin A/CDK2 complex
- part of a SCF- like complex consisting of CUL7, RBX1, SKP1 & FBXW8
- component of an E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC & TBL1X
- component of the SCF(BTRC) complex, composed of SKP1, CUL1 & BTRC
- part of a SCF(BTRC)-like complex lacking CUL1, which is associated with phosphorylated NFKBIA & RELA
Structure: belongs to the SKP1 family
Alternative splicing: named isoforms=2
Related
cyclin A
cyclin-dependent kinase-2 (CDK2)
General
Skp (S phase kinase associated protein) family protein
Properties
SIZE: entity length = 163 aa
MW = 19 kD
MOTIF: F-box interaction {104-163}
Database Correlations
OMIM 601434
UniProt P63208
PFAM correlations
Entrez Gene 6500
Kegg hsa:6500
References
- UniProt :accession P63208
- Zhang et al.
p19Skp1 and p45Skp2 are essential elements of the cyclin A-
CDK2 S phase kinase.
Cell 82:915-25 1995
PMID: 7553852
Component-of
some large E3 complex